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Bithionol sulfoxide

Product NameBithionol sulfoxide
CAS844-26-8
MFC12H6Cl4O3S
MW372.05
EINECS212-679-2
MOL File844-26-8.mol

Chemical Properties

Melting point	220 °C(Solv: methanol (67-56-1))
Boiling point	532.7±50.0 °C(Predicted)
Density	1.86±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥ 250 mg/mL (671.95 mM)
form	Solid
pka	4.79±0.48(Predicted)
color	White to off-white

Safety Information

WGK Germany	3
RTECS	SM8800000

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection[1][2][5].

in vivo

Bithionol sulfoxide (oral administration) shows LD₅₀ values of 1000-5000 mg/kg (mice) and about 5000 mg/kg (rats), and increased serum AST at high doses (5000-100 mg/kg)^[3].
Bithionol sulfoxide (80 and 90 mg/kg, oral administration) is effective against natural rumen fluke infections in dairy cattle^[4].

Animal Model:	Dairy cattle^[4]
Dosage:	60, 80 90 mg/kg
Administration:	Oral administration
Result:	Showed approximately 70% effective against rumen flukes infection at dosages of 80 and 90 mg/kg after one week post treatment.

IC 50

Schistosome

References

[1] Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. DOI:10.3354/dao02269
[2] S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. DOI:10.1378/chest.52.2.220
[3] Lavri A, et al. Oral toxicity of bithionol sulfoxide in mice and rats. Zbornik Veterinarske Fakultete Univerza Ljubljana 1990 Vol.27 No.1 pp.33-39 ref.22.
[4] Chompoochan T, et al. The anthelmintic effects of bithionol sulfoxide against sheep experimentally infected with Fasciola gigantica[C]//ACIAR PROCEEDINGS. 1996: 189-194.
[5] D.Mourot, et al. Mutagenicity of bithionol sulfoxide and its metabolites in the Salmonella/mammalian microsome test. Mutation Research/Genetic Toxicology, 1987, 188(1): 53-55.

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