Quercetin 3-(6″-caffeoylsophoroside) (50, 100, 500, 1000, and 2000 mg/kg, p.o.) shows safety in acute oral toxicity of SD rats and can be used in anti-diabetic research[1].
Quercetin 3-(6″-caffeoylsophoroside) (125, 250, 500 mg/kg, p.o.) improves type 2 diabetes mellitus of SD rats by oxidative stress reduction and α-amylase inhibition[1].
| Animal Model: | FED HFD (45% fat) for 30 days to induce type 2 diabetes mellitus in SD rats[1] |
| Dosage: | 125, 250, 500 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Significantly decreased the blood glucose level, improved biochemical parameters as well as oxidative stress by reduction of lipid peroxidation, and increased high-density lipoproteins with dose of 500mg/kg.
Enhanced activities of glutathione-s-transferase, glutathione, superoxide dismutase.
Restored cellular architecture in the histopathological examination.
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| Animal Model: | Acute oral toxicity in 8-week male SD rats[1] |
| Dosage: | 50, 100, 500, 1000, and 2000 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Safe for use in anti-diabetic research.
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