Peptide021(P021)

Derived from amino acids 139–164 of the C-terminus of the full-length p21 protein, the Peptide021(P021) interferes with proliferating cell nuclear antigen (PCNA) function and lacks organized structure in its free form[1][2]. The p21C2 peptide serves as a precursor to analyze whether S phase is inhibited by microinjection[1].

[1] Chen, J., Peters, R., Saha, P., Lee, P., Theodoras, A., Pagano, M., Wagner, G., & Dutta, A. (1996). A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acids Research, 24 9, 1727–1733. https://doi.org/10.1093/nar/24.9.1727
[1] Walker, L. R., Ryu, J. S., Perkins, E., McNally, L. R., & Raucher, D. (2014). Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer. Drug Design, Development and Therapy, 1649–1658. https://doi.org/10.2147/DDDT.S60451