S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can also inhibit methylation of both farnesylated and geranylgeranylated substrates.
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.
ChEBI: 2-(3,7,11-trimethyldodeca-2,6,10-trienylthio)acetic acid is a sesquiterpenoid.
[1] RANDO R R. Chemical biology of protein isoprenylation/methylation[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1996, 1300 1: Pages 5-16. DOI:
10.1016/0005-2760(95)00233-2
