Tritoqualine
Tritoqualine 性质
| 熔点 | 183° |
|---|---|
| 沸点 | 647.2±55.0 °C(Predicted) |
| 密度 | 1.296±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.22±0.40(Predicted) |
Tritoqualine 用途与合成方法
histidine decarboxylase
The effect of Tritoqualine (TRQ) on the CCl 4 -induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl 4 . Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl 4 -stimulated lipid peroxidation at a concentration of 33 μM.
A single administration of CCl 4 (0.75 mL/kg, p.o.) causes a five-fold increase of in vivo lipid peroxidation in the liver. In contrast, a reduction of 37% in the lipid peroxidation is obtained by Tritoqualine (100 mg/kg) pretreatment for 14 days prior to CCl 4 treatment. A 63% reduction is observed in vitamin E (25 mg/kg) pretreated rats.
