Methyl-4-amino-3-fluorobenzoate

185629-31-6

185629-32-7

General procedure for the synthesis of methyl 4-amino-3-fluorobenzoate from methyl 3-fluoro-4-nitrobenzoate: Methyl 3-fluoro-4-nitrobenzoate (2.50 g, 12.5 mmol) and Pd/C catalyst (300 mg, 10 wt%) were placed in a 1:1 EtOAc/EtOH solvent mixture (40 mL). The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 16 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford methyl 4-amino-3-fluorobenzoate (2.1 g, 99% yield) as a beige solid. Mass spectrometry analysis (ES+): the theoretical molecular weight of C8H8FNO2 was 169 and the measured value was 170 [M + H]+.