Pyrimidine, 2-ethynyl- (9CI)

193631-86-6

37972-24-0

General procedure for the synthesis of 2-ethynylpyrimidine from the compound (CAS: 193631-86-6): 1 M TBAF (18.5 mL, 18.5 mmol) was added to 3 mL (3.2 g, 18.5 mmol) of a 10 mL solution of THF, and the reaction was carried out for 3 min. Monitoring by TLC showed complete consumption of the feedstock. Subsequently, the reaction mixture was concentrated under vacuum. The crude product was purified by silica gel column chromatography to afford the target product 4 (1.3 g, yield: 68.8%).LCMS analysis showed m/z of 105 ([M + H]+).