KAROUNIDIOL

Karounidiol exhibits cytotoxicity especially against a human renal cancer. Karounidiol markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).

Karounidiol is a triterpenoid that can be found in Trichosanthes kirilowii. [1].

ChEBI: Karounidiol is an organic hydroxy compound.

[1] Akihisa T, et al. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 2001 Nov 8;173(1):9-14. DOI:10.1016/s0304-3835(01)00689-9