(S)-Tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-YN-1-YL)pyridin-2-YL)-2-(3,5-difluorophenyl)ethyl)carbamate is a pharmaceutical intermediate compound that can be used in the preparation of HIV inhibitors.
(S)-tert-butyl (1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate is a key pharmaceutical intermediate for lenapavir (trade name Sunlenca), used in the synthesis of anti-HIV-1 drugs. Lenapavir is a first-in-class long-acting HIV-1 capsid inhibitor administered subcutaneously, providing a prolonged treatment period, significantly reducing the treatment burden on patients, and exhibiting potent antiviral activity against drug-resistant HIV strains.
[1] Rajan, Srinivasan Thirumalai, et al. "Process for the preparation of tert-butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl) but-1-yn-1-yl) pyridin-2-yl)-2-(3, 5-difluorophenyl) ethyl) carbamate." (2026).
