Commercial production of dichlobentiazox begin with succinonitrile, which is chlorinated thermally to give a mixture of maleonitrile and fumaronitrile dichlorides. This mixture is then reacted with disulphur dichloride, forming the key trisubstituted isothiazole scaffold. Subsequent nitrile hydrolysis produces the corresponding carboxylic acid, which is then incorporated into the final dual-isothiazole fungicide structure through controlled coupling and purification steps to yield technical-grade dichlobentiazox suitable for formulation.
