Cotadutide (10nmol/kg, s.c., once) suppresses food intake in DIO mice relative to vehicle‐treated controls[1].
Cotadutide (10 or 30nmol/kg, s.c., once daily for 14-16 weeks) reduces body weight in DIO mice[1].
Cotadutide (30 nmol/kg, s.c., once a day for 6 weeks) reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice[2].
| Animal Model: | Diet-induced obesity (DIO) mice[1] |
| Dosage: | 10nmol/kg |
| Administration: | Subcutaneousinjection (s.c.) |
| Result: | Showed a redction of food intake in mice after an acute administration. |
| Animal Model: | Diet-induced obesity (DIO) mice[1] |
| Dosage: | 10 or 30nmol/kg |
| Administration: | Subcutaneousinjection (s.c.) |
| Result: | Reduced body weight and food intake, and improved glucose tolerance in DIO mice. |
