2,6-DIHYDROXY-3,9-DIMETHYLPURINE

3,9-Dimethylxanthine has been used to study the molecular mechanism of in situ activation of ryanodine receptors (RY) in pancreatic β cells from ob/ob mice.

3,9-Dimethylxanthine is a xanthine derivative. It has been reported to be an activator of ryanodine receptor (RY). Mechanism of its electrochemical oxidation has been investigated in the pH range 3.0-10.8 at stationary pyrolytic graphite electrode. It has been synthesized by reacting 1-methyl-5-(methylamino)-imidazole-4-carboxamide with EtOCOCl in acetate buffer (pH5), followed by the reaction with aqueous NaOH.