Arbaprostil (15(R)-
15-
methyl prostaglandin E
2) is a synthetic prostaglandin E
2 (PGE
2) analog developed for its cytoprotective activity.
1 15(R)-
15-
methyl Prostaglandin A
2 (15(R)-
15-
methyl PGA
2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.
2 The pharmacology and EP receptor binding affinity for 15(R)-
15-
methyl PGA
2 has not been published.
1. Collins, P.W. Misoprostol: Discovery, development, and clinical applications Med. Res. Rev. 10(2),149-172(1990).
2. Kissinger, L.D., and Robins, R.H. Silver-modified mobile phase for normal-phase liquid chromatographic determination of prostaglandins and their 5,6-trans isomers in prostaglandin bulk drugs and triacetin solutions J. Chromatogr. 321(2),353-362(1985).
