Leptin (22-56), human

Product NameLeptin (22-56), human
CAS183598-56-3
MFC171H298N50O56
MW0
EINECS
MOL FileMol File

Chemical Properties

storage temp.	-15°C
form	Solid
color	White to off-white
Sequence	H-Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val-Ser-Ser-Lys-Gln-Lys-OH

Usage And Synthesis

Uses

Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).

Biological Activity

Leptin (22-56), human is a polypeptide fragment of leptin that acts through various isoforms of Ob-Rs.

in vitro

Leptin (22-56), human is the fragment of leptin, inhibits corticosterone production, but shows no effect on the proliferation of cultured adrenocortical cells. It may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adrenocortical cells. It inhibits food intake, and may favour erythropoiesis.

References

[1] Malendowicz LK, et al. Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells. Int J Mol Med. 2004 Nov;14(5):873-7. PMID:15492859
[2] Stamatiadis DN, et al. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. Clin Endocrinol (Oxf). 2004 Apr;60(4):434-41. DOI:10.1111/j.1365-2265.2004.01999.x