S-NITROSOGLUTATHIONE

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.

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A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation

S-Nitrosoglutathione (GSNO) has been used:

• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

ChEBI: S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a platelet aggregation inhibitor, a bronchodilator agent, a nitric oxide donor and a signalling molecule. It is a glutathione derivative and a nitrosothio compound. It is a conjugate acid of a S-nitrosoglutathione(2-).

A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.

Product does not compete with ATP.

Desiccate at -20°C

[1] MAREK W. RADOMSKI. S-nitroso-glutathione inhibits platelet activation in vitro and in vivo[J]. British Journal of Pharmacology, 1992, 107 3: 745-749. DOI: 10.1111/j.1476-5381.1992.tb14517.x
[2] ANTHONY R. ANTHONY  Peter R. Chemistry, Analysis, and Biological Roles ofS-Nitrosothiols[J]. Analytical biochemistry, 1997, 249 1: Pages 1-9. DOI: 10.1006/abio.1997.2129
[3] A GASCO  G S  R Fruttero. No-donors: an emerging class of compounds in medicinal chemistry.[J]. Farmaco (Societa chimica italiana: 1989), 1996, 51 10: 617-635.
[4] JOHN A. COOK . Convenient Colorimetric and Fluorometric Assays for S-Nitrosothiols[J]. Analytical biochemistry, 1996, 238 2: Pages 150-158. DOI: 10.1006/abio.1996.0268