8-Bromoadenosine 5′-triphosphate (sodium salt hydrate)

8-Bromoadenosine 5’-triphosphate (8-Br-ATP) is an analog of ATP (Item No. 14498) and an agonist of the purinergic P2X receptor.1 It induces contraction of isolated guinea pig bladder strips with a potency that is 0.19-fold that of ATP. 8-Br-ATP has been used in the determiniation of the nucleotide substrate specificity of yeast poly(A) polymerase.2 It is cytotoxic to multiple myeloma cells (IC50 = 23.1 μM).3WARNING This product is not for human or veterinary use.

[1] WILLIAM HOWSON . Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)[J]. European Journal of Medicinal Chemistry, 1988, 23 5: Pages 433-439. DOI: 10.1016/0223-5234(88)90140-7
[2] LISA S CHEN  Terry L S. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs.[J]. The Journal of Biological Chemistry, 2004, 279 39: 40405-40411. DOI: 10.1074/jbc.m401752200
[3] LI WANG  Robert C M. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells.[J]. Journal of Liposome Research, 2011, 21 4: 306-314. DOI: 10.3109/08982104.2011.565476