CYTIDINE 5'-TRIPHOSPHATE DISODIUM

Product NameCYTIDINE 5'-TRIPHOSPHATE DISODIUM
CAS652154-13-7
MFC9H14N3Na2O14P3
MW527.12
EINECS252-849-3
MOL File652154-13-7.mol

Chemical Properties

Flash point	>230 °F
storage temp.	-20°C
solubility	H2O: soluble50mg/mL, clear, colorless
form	A crystalline solid
Water Solubility	H2O: 50mg/mL, clear, colorless
BRN	3582735
InChIKey	IJMSOWKYYIROGP-LLWADOMFSA-L
SMILES	O.[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O

Safety Information

WGK Germany	3
F	10-21
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

Cytidine 5''-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate. This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer. CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.

Uses

Cytidine 5′-triphosphate disodium salt hydrate has been used:

in the oligonucleotide synthesis for silver nanoclustersinteraction studies
as an anion source for fluorescence emission and titration curve-analysis of hypocrellin A-zinc(II) complex
in fluorescence emission experiments of copper(II)–2,6-bis(2-benzimidazolyl)pyridine complex

Biochem/physiol Actions

Cytidine 5′-triphosphate (CTP) is essential for the synthesis of DNA and is a mediator of many physiological processes in living systems. It is crucial for the dolichol phosphorylation, cholesterol transport and is involved in the allosteric regulation of aspartate transcarbamylase. It is also used in the treatment of disease related brain.

References

[1] ZHAOYU LI Dennis E V. Phosphatidylcholine and choline homeostasis.[J]. Journal of Lipid Research, 2008: 1187-1194. DOI: 10.1194/jlr.r700019-jlr200
[2] THOMAS A. LAGACE Neale D R. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum[J]. Biochimica et biophysica acta. Molecular cell research, 2013, 1833 11: Pages 2499-2510. DOI: 10.1016/j.bbamcr.2013.05.018
[3] DANIEL J ARSENAULT. ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.[J]. The Journal of Biological Chemistry, 2013, 288 1: 633-643. DOI: 10.1074/jbc.m112.347682
[4] J VIONNET. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands.[J]. Glycobiology, 1999, 9 5: 481-487. DOI: 10.1093/glycob/9.5.481

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