JTV-519 HEMIFUMARATE
中文名称:JTV-519 HEMIFUMARATE
英文名称:JTV-519 hemifumarate
CAS号:1435938-25-2
分子式:C29H36N2O6S
分子量:540.68
EINECS号:
Mol文件:1435938-25-2.mol
![JTV-519 HEMIFUMARATE 结构式](https://img.chemicalbook.com/CAS/20211123/GIF/1435938-25-2.gif)
JTV-519 HEMIFUMARATE 用途与合成方法
JTV-519 hemifumarate (K201 hemifumarate) 是 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂。JTV-519 hemifumarate (K201 hemifumarate) 也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 hemifumarate (K201 hemifumarate) 是一种心脏保护剂,具有抗心律失常作用。
JTV-519 (K201) inhibits inward Ca 2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca 2+ , 3 μM JTV-519 shows significant inhibition of Ca 2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201.
JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment.
Animal Model: | Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) |
Dosage: | 0.5 mg/kg/h |
Administration: | Applied intraperitoneally 2 h before the surgery |
Result: | Improved cardiac function, where the EF and FS were significantly increased. |
JTV-519 HEMIFUMARATE供应商 更多
四川省维克奇生物科技有限公司
联系电话:028-81700200 18116577057
产品介绍:
中文名称:暂无
英文名称:JTV-519hemifumarate
CAS:1435938-25-2
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
天津凯利奇生物科技有限公司
联系电话: 15076683720
产品介绍:
英文名称:JTV-519 hemifumarate
CAS:1435938-25-2
纯度:大于98%
包装信息:1g,5g,10g,25g根据客户需要分装
备注:Not For Human Use, Lab Use Only.
天津普西唐生物医药科技有限公司
联系电话:010-60605840
产品介绍:
英文名称:JTV-519 hemifumarate
CAS:1435938-25-2
包装信息:100mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 T11732
英文名称:JTV-519 hemifumarate;JTV 519 hemifumarate,JTV519 hemifumarate
CAS:1435938-25-2
纯度:98%
包装信息:10 mg