CUL3 is a member of the cullin-based ubiquitin ligase family. By interacting with Hrt1 and BTB domain containing proteins, the complex functions as a CUL3-based E3 ligase to bring specific substrates to ubiquitinylation and degradation. The CUL3 complex has been shown to target many substrates involved in cell cycle progression, transcription, development and differentiation.
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