Background
CUL3 is a member of the cullin-based ubiquitin ligase family. By interacting with Hrt1 and BTB domain containing proteins, the complex functions as a CUL3-based E3 ligase to bring specific substrates to ubiquitinylation and degradation. The CUL3 complex has been shown to target many substrates involved in cell cycle progression, transcription, development and differentiation.
References
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