MM-589 TFA (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.
Cell Viability Assay
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Cell Line:
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MV4-11 and MOLM-13 cells
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Concentration:
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0.01, 0.1, 1, 10 μM
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Incubation Time:
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4 days or 7 days
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Result:
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Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM.
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