MM-589 TFA salt
- Product NameMM-589 TFA salt
- CAS2097887-21-1
- CBNumberCB24675387
- MW0
- EINECS-0
- MDL NumberMFCD32689433
- MOL FileMol file
Chemical Properties
| storage temp. | -20°C, away from moisture |
| solubility | DMSO : 25 mg/mL (36.40 mM; ultrasonic and warming and heat to 60°C) |
MM-589 TFA salt Chemical Properties,Usage,Production
Biological Activity
MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interactions. MM-MM-589 TFA binds WDR5 with an IC50 of 0.90 nM. IC50 for inhibition of MLL H3K4 methyltransferase activity is 12.7 nM.in vitro
MM-589 TFA (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.Cell Viability Assay < table class="zh_use_1"> < tr>
| Cell Line: | MV4-11 and MOLM-13 cells |
| Concentration: | 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 4 days or 7 days |
| Result: | Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM. |
target
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)
Ki: <1 nM (WDR5)
Preparation Products And Raw materials
MM-589 TFA salt Suppliers
Global(19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 | |
| +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 | |
| +86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 | |
| 0510-85629785 18013409632 |
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| 0571-87213919 | eric@peptidego.com | China | 6527 | 58 | |
| 18818260767 | sales@chemegen.com | China | 11289 | 58 | |
| 88888888888 | hongquchem@qq.com | China | 5132 | 58 | |
| 0510-85629785 18013409632 |
sales@reading-chemicals.com | China | 14092 | 58 | |
| 15869524721 | 3525679403@qq.com | China | 3615 | 58 |
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