Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1].
in vivo
CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats[1].
Animal Model:
Male Sprague-Dawley rats (≈250 g)[1]
Dosage:
3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:
Subcutaneously (s.c.); five days.
Result:
30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points.
References
[1] Elizabeth T Nguyen, et al. A Mixed Glucocorticoid/Mineralocorticoid Receptor Modulator Dampens Endocrine and Hippocampal Stress Responsivity in Male Rats. Physiol Behav. 2017 Sep 1;178:82-92. DOI:10.1016/j.physbeh.2017.01.020
