(11(12)-DiHET-d11

(±)11(12)-DiHET-d11 is intended for use as an internal standard for the quantification of 11(12)-DiHET by GC- or LC-MS. 11(S),12(S)-DiHET and 11(R),12(R)-DiHET are vicinal diols formed via enzymatic hydration of 11(12)-EET by cytosolic or soluble epoxide hydrolases in a non-stereoselective manner.1,2,3WARNING This product is not for human or veterinary use.

[1] X FANG. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle.[J]. Circulation research, 1996, 79 4: 784-793. DOI: 10.1161/01.res.79.4.784
[2] D C ZELDIN. Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.[J]. The Journal of Biological Chemistry, 1993, 268 9: 6402-6407.
[3] GUODONG ZHANG  Bruce D H  Sean Kodani. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer[J]. Progress in lipid research, 2014, 53: Pages 108-123. DOI: 10.1016/j.plipres.2013.11.003