METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
中文名称:METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
英文名称:1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester
CAS号:2097938-51-5
分子式:C20H19ClN6O2
分子量:410.86
EINECS号:
Mol文件:2097938-51-5.mol
![METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 结构式](https://img.chemicalbook.com/CAS/20200331/GIF/2097938-51-5.gif)
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 性质
| 密度 | 1.465±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：62.5 mg/mL（152.12 mM；需要超声波） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.68±0.10(Predicted) |
| 颜色 | 米白色至粉红色 |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 用途与合成方法
R-10015 是一种有效的、具有选择性的 LIM domain kinase (LIMK) 抑制剂，对于人LIMK1的IC50值为38 nM。R-10015 会结合到 ATP-binding pocket 上，并充当HIV感染的广谱抗病毒化合物。
| Target | Value |
|
hLIMK1
(Cell-free assay) | 38 nM |
R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.
R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .
Western Blot Analysis
| Cell Line: | CEM-SS T cells |
| Concentration: | 100 μM |
| Incubation Time: | 0 hour,0.5 hour,1 hour,2 hours,4 hours |
| Result: | Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. |
R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.
| Animal Model: | 6-8 weeks female C3H/HeN mice |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Displayed none indication of toxicity. |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-120097 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE | 2097938-51-5 | 1 mg | 610 |
| 2026-09-15 | HY-120097 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE | 2097938-51-5 | 5 mg | 1488 |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE供应商 更多
上海毕得医药科技股份有限公司
联系电话：400-164-7117 18317119277
产品介绍：
中文名称：2-(1-(5-氯-7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-基)-1H-苯并[d]咪唑-6-羧酸甲酯
英文名称：Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate
CAS：2097938-51-5
纯度：98+%
包装信息：1mg;5mg;10mg;25mg;50mg;100mg
备注：BD01144504
天津凯利奇生物科技有限公司
联系电话： 15076683720
产品介绍：
中文名称：2-(1-(5-氯-7H-吡咯并[2,3-D]嘧啶-4-基)哌啶-4-基)-1H-苯并[D]咪唑-6-羧酸甲酯
英文名称：1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester
CAS：2097938-51-5
纯度：大于98%
包装信息：1g,5g,10g,25g根据客户需要分装
备注：Not For Human Use, Lab Use Only.
上海超岚化工科技中心
联系电话：QQ：65489617 13301690235
产品介绍：
英文名称：R-10015
CAS：2097938-51-5
纯度：98
包装信息：1G,5G,10G,50G,100G,500G
备注：仅用于药证申报和科学研究，不为任何个人提供产品和服务
最新发布供应信息
aladdin 阿拉丁 R413653 R-10015 2097938-51-5 96%
上海阿拉丁生化科技股份有限公司
2026-10-14
化合物 R-10015|T12609|TargetMol
TargetMol中国（陶术生物）
2026-09-26
