生物活性 靶点 体外研究 体内研究 METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 试剂级价格
ChemicalBook  CAS数据库列表  METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE

METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE

METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE,2097938-51-5,结构式
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
  • CAS号:2097938-51-5
  • 英文名:1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester
  • 中文名:METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
  • CBNumber:CB24657880
  • 分子式:C20H19ClN6O2
  • 分子量:410.86
  • MOL File:2097938-51-5.mol
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE化学性质
  • 密度 :1.465±0.06 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMSO : 62.5 mg/mL (152.12 mM; Need ultrasonic)
  • 形态 :Solid
  • 酸度系数(pKa) :10.68±0.10(Predicted)
  • 颜色 :Off-white to pink

METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE性质、用途与生产工艺

  • 生物活性 R-10015 是一种有效的、具有选择性的 LIM domain kinase (LIMK) 抑制剂,对于人LIMK1的IC50值为38 nM。R-10015 会结合到 ATP-binding pocket 上,并充当HIV感染的广谱抗病毒化合物。
  • 靶点
    TargetValue
    hLIMK1
    (Cell-free assay)
    38 nM
  • 体外研究

    R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
    R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.
    R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .

    Western Blot Analysis

    Cell Line: CEM-SS T cells
    Concentration: 100 μM
    Incubation Time: 0 hour,0.5 hour,1 hour,2 hours,4 hours
    Result: Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
  • 体内研究

    R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.

    Animal Model: 6-8 weeks female C3H/HeN mice
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection
    Result: Displayed none indication of toxicity.
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE上下游产品信息
上游原料
下游产品
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:S6837
  • 产品名称:METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015
  • CAS编号:2097938-51-5
  • 包装:2mg
  • 价格:1870.64元
  • 更新日期:2024/11/08
  • 产品编号:S6837
  • 产品名称:METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015
  • CAS编号:2097938-51-5
  • 包装:5mg
  • 价格:3700.86元
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE生产厂家
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