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5-Amino-4-imidazolecarboxamide

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5-Amino-4-imidazolecarboxamide Basic information
5-Amino-4-imidazolecarboxamide Chemical Properties
  • Melting point:164-170 °C(lit.)
  • Boiling point:234.22°C (rough estimate)
  • Density 1.3659 (rough estimate)
  • refractive index 1.8500 (estimate)
  • storage temp. -20°C Freezer
  • pka11.97±0.10(Predicted)
  • form Powder
  • color White
  • Water Solubility Soluble in DMSO, Methanol, Water.
  • InChIKeyDVNYTAVYBRSTGK-UHFFFAOYSA-N
  • CAS DataBase Reference360-97-4(CAS DataBase Reference)
  • EPA Substance Registry System1H-Imidazole-4-carboxamide, 5-amino- (360-97-4)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS NI3910000
  • TSCA Yes
  • HS Code 29332900
MSDS
5-Amino-4-imidazolecarboxamide Usage And Synthesis
  • Description5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR).It is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. When compounded with orotic acid, it is used to treat liver diseases.
  • Reference3. Black, S. L., M. J. Black, and J. H. Mangum. "A rapid assay for 5-amino-4-imidazolecarboxamide ribotide transformylase." Analytical Biochemistry90.1(1978):397-401.
  • Chemical PropertiesWhite to Off-White Solid
  • UsesA metabolite of Temozolomide
  • DefinitionChEBI: An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.
5-Amino-4-imidazolecarboxamide Preparation Products And Raw materials
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