6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol

ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability.

ZINC05626394 is a cytochrome b5 reductase 3 inhibitor with activity by increasing nitric oxide bioavailability. ZINC05626394 may have potential applications in anti-cancer suppression, especially in combination with antibody drug conjugates (ADCs) and immune checkpoint inhibitors. The efficacy of ZINC05626394 may be limited by different mechanisms, including antigen-related resistance and failure of endocytosis[1].

[1] Mechanisms of Resistance to Antibody-Drug Conjugates DOI:10.1074/jbc.M114.629964