NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D) is involved in major biosynthetic pathway of anandamide and other bioactive N-acylethanolamines. It accelerates the hydrolysis of NAPE to N-acylethanolamine and phosphatidic acid. It exerts zinc dependent catalytic activity while generating N-acylethanolamines including anandamide from their corresponding NAPEs, highly responsible for zinc coordination and hydrolysis reaction. It also plays a significant role in the lipid metabolism of animal tissues.
