4-Hydroxy-3-methoxycinnamaldehyde is suitable for use in a study to investigate the antioxidant and antiradical activities of ferulates using a β-carotene-linoleate model system and a DPPH radical scavenging assay, respectively.
ChEBI: A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.
4-Hydroxy-3-methoxycinnamaldehyde is an isoflavonoid. It has been isolated from the insecticidally active hot dichloromethane extract of heartwood of Gliricidia sepium, seed kernels of Melia azedarach L and barks of Cinnamomum cebuense.
Coniferaldehyde (0.05 mmol kg/day; i.p; for 6 weeks) activates the Nrf2 signaling pathway in primary chondrocytes and articular cartilage from the knee joints. And Coniferaldehyde alleviates cartilage destruction in OA mice[2].
| Animal Model: | B6 male mice (26 g; 8-10 weeks old), surgical-induced osteoarthritis (OA)[2] |
| Dosage: | 0.05 mmol kg/day (approx. 8.9 mg/kg) |
| Administration: | i.p; for 6 weeks |
| Result: | Evidently alleviated the medial meniscus cartilage damage in mice subjected to the destabilization. |
