(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC₅₀ = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC₅₀s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC₅₀s = 7.9, 7.2, and 7 μM, respectively).

(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM.

HDAC8: 27.2 nM (IC₅₀)

[1] DR. WEI-JAN HUANG. Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors[J]. ChemMedChem, 2012, 7 10: 1815-1824. DOI: 10.1002/cmdc.201200300