五味子丙素
五味子丙素 性质
| 熔点 | 122-123℃ |
|---|---|
| 沸点 | 549.2±50.0 °C(Predicted) |
| 密度 | 1.232 |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：8.33 mg/mL（21.67 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 颜色 | 白色 |
| 主要应用 | 代谢组学 维生素、营养保健品和天然产品 |
| InChI | 1S/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3 |
| InChIKey | HTBWBWWADZJXID-UHFFFAOYSA-N |
| SMILES | COC1=C2C(OCO2)=CC3=C1C(C(OC)=C(OCO4)C4=C5)=C5CC(C)C(C)C3 |
| LogP | 5.623 (est) |
五味子丙素 用途与合成方法
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).
Western Blot Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the expression of apoptosis related proteins. |
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced cell apoptosis. |
Cell Cycle Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced growth inhibition and G1 arrest of U937 cells. |
Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.
| Animal Model: | Aβ1-42-induced Alzheimer’s disease mice |
| Dosage: | 15-150 μg/kg |
| Administration: | Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days |
| Result: | Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. |
五味子丙素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-N0690 | 五味子丙素 | 61301-33-5 | 5 mg | 937 |
| 2026-06-05 | HY-N0690 | 五味子丙素 | 61301-33-5 | 10 mM * 1 mL in DMSO | 1030 |
