UR-144 is a synthetic cannabinoid (CB) analog of JWH 018 in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB2 receptor. UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.
3,??3,??4-??Trimethyl-??1-??(1-??pentyl-??1H-??indol-??3-??yl)??-4-??penten-??1-??one is a potent agonist for the peripheral CB2 receptor and a synthetic cannabinoid. It can be used to develop analytical assays that detects UR-??144 and its metabolites.
