O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice[1].
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].
| Animal Model: | Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet[1] |
| Dosage: | 6, 12 mg/kg |
| Administration: | A single i.p. |
| Result: | Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.
The highest dose significantly counteracted the body weight increase. |
