FRAX1036
FRAX1036 性质
| 沸点 | 669.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1?+-.0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 9.46±0.10(Predicted) |
| 颜色 | 白色至浅黄色 |
FRAX1036 用途与合成方法
|
PAK1 23.3 nM (Ki) |
PAK2 72.4 nM (Ki) |
PAK4 2.4 μM (Ki) |
FRAX1036 is a PAK inhibitor with K i s of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 μM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells. FRAX1036 (10 μM) affects the proliferation of non-small cell lung cancer (NSCLC) cells when added to KRAS prenylation inhibitors.
FRAX1036 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-19538 | FRAX1036 | 1432908-05-8 | 1mg | 600 |
| 2024-11-08 | HY-19538 | FRAX1036 | 1432908-05-8 | 5mg | 1100 |
