罗汉松酸
罗汉松酸 性质
| 熔点 | 193-196 °C (lit.) |
|---|---|
| 比旋光度 | 20546 +165° (c = 4 in abs ethanol) |
| 沸点 | 449.6±45.0 °C(Predicted) |
| 密度 | 1.182±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥ 100 mg/mL（364.50 mM） |
| 酸度系数(pKa) | 4.66±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 旋光性 (optical activity) | [α]20/D +133°, c = 4 in ethanol |
| Merck | 13,7625 |
罗汉松酸 用途与合成方法
Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells.
Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca 2+ flux, which is significantly reduces when the Ca 2+ -impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels.
罗汉松酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N2318 | 5 mg | 350 | ||
| 2024-11-08 | HY-N2318 | 罗汉松酸 | 5947-49-9 | 10mg | 500 |
