Mal-PEG1-NHS ester

Product NameMal-PEG1-NHS ester
CAS1807518-72-4
MFC13H14N2O7
MW310.26
EINECS
MOL File1807518-72-4.mol

Chemical Properties

Boiling point	488.4±55.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
solubility	Soluble in DCM
pka	-2.35±0.20(Predicted)
form	Solid
color	White to off-white
InChI	InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
InChIKey	AMRJPIJPLBUEHO-UHFFFAOYSA-N
SMILES	C(ON1C(=O)CCC1=O)(=O)CCOCCN1C(=O)C=CC1=O

Usage And Synthesis

Description

Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Biological Activity

Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target