This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq)
GABPB1 (GA binding protein transcription factor, β subunit 1) plays a key role in transcriptional regulation. It has ability to form homodimer as well as heterodimer with GABPβ1L. It has been predicted th at GABPB1 exerts a distinct role in regulating lymphocyte development including B cell expansion and humoral responses. GABPB1 controls autophagy through the activation of BECN1-PIK3C3 (Beclin 1-phosphatidylinositol 3-kinase) complex.
