Dodecylphosphorylcholine-d38

Dodecylphosphocholine-d₃₈ is intended for use as an internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR. It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane. Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)). Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.

MAPCHO-12-d38 has been used in the preparation of drug complexes used as a sample during nuclear magnetic resonance (NMR) spectroscopy.

[1] VILIUS KURAUSKAS. How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.[J]. The Journal of Physical Chemistry Letters, 2018, 9 5: 933-938. DOI: 10.1021/acs.jpclett.8b00269
[2] SARAH D. CADY. Specific Binding of Adamantane Drugs and Direction of Their Polar Amines in the Pore of the Influenza M2 Transmembrane Domain in Lipid Bilayers and Dodecylphosphocholine Micelles Determined by NMR Spectroscopy[J]. Journal of the American Chemical Society, 2011, 133 12: 4274-4284. DOI: 10.1021/ja102581n
[3] S. SAUVé Y A. Dodecylphosphocholine Micelles Induce Amyloid Formation of the PrP(110-136) Peptide via an α-Helical Metastable Conformation[J]. PLoS ONE, 2016, 11 1. DOI: 10.1371/journal.pone.0168021