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FLLL31

Product NameFLLL31
CAS52328-97-9
MFC25H28O6
MW424.49
EINECS
MOL File52328-97-9.mol

Chemical Properties

Melting point	69-71 °C
Boiling point	594.5±50.0 °C(Predicted)
Density	1.140±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	yellow
InChI	1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+
InChIKey	VMMZAMVBGQWOHT-UTLPMFLDSA-N
SMILES	COc1ccc(\C=C\C(=O)C(C)(C)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 4

Usage And Synthesis

Uses

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].

Biological Activity

Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.

in vitro

Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.

target

STAT3

IC 50

STAT3

References

[1] Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res.2010 Mar 15;70(6):2445-54. DOI:10.1158/0008-5472.CAN-09-2468
[2] Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol.2014 Jul;21(1):128-36. DOI:10.1016/j.intimp.2014.04.020

Preparation Products And Raw materials

FLLL31 Supplier

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