Cilliobrevin D
Cilliobrevin D 性质
| 沸点 | 591.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.537±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：5 mg/mL（12.73 mM；超声加热并加热至 80°C） |
| 酸度系数(pKa) | 5.99±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
Cilliobrevin D 用途与合成方法
| Target | Value |
|
cytoplasmic dynein
() | |
|
Hedgehog
() |
Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Similar Ciliobrevin-induced spindle defects are observed in HeLa cells, although to a lesser extent. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.
.
Ciliobrevin D reversibly inhibits melanosome aggregation, but the non-cilia-disrupting derivative had no discernible effect at comparable doses. Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells.
Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8.
Cilliobrevin D 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-08-19 | S9743 | Cilliobrevin D | 1370554-01-0 | 5mg | 1613.93 |
| 2024-08-19 | S9743 | Cilliobrevin D | 1370554-01-0 | 25mg | 4832.94 |
