阿塞那平盐酸盐
阿塞那平盐酸盐 用途与合成方法
|
sPLA2 2.5 nM (Ki) |
5-HT 2A Receptor 0.06 nM (Ki) |
5-HT 2C Receptor 0.03 nM (Ki) |
5-HT 7 Receptor 0.13 nM (Ki) |
D 2 Receptor 1.3 nM (Ki) |
D 3 Receptor 0.42 nM (Ki) |
D 4 Receptor 1.1 nM (Ki) |
Relative to its D2 receptor affinity, Asenapine has a higher affinity for 5-HT 2C , 5-HT 2A , 5-HT 2B , 5-HT 7 , 5-HT 6 , α 2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pK B ) at 5-HT 1A (7.4), 5-HT1B (8.1), 5-HT 2A (9.0), 5-HT 2B (9.3), 5-HT 2C (9.0), 5-HT 6 (8.0), 5-HT 7 (8.5), D2 (9.1), D3 (9.1), α 2A (7.3), α 2B (8.3), α 2C (6.8) and H1 (8.4) receptors.
Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice.
阿塞那平盐酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-16567 | 5 mg | 406 | ||
| 2024-04-30 | HY-16567 | 阿塞那平盐酸盐 | 1412458-61-7 | 10mg | 650 |
