Enprostil is one of three, orally-active prostaglandins (see rnisoprostol and
rosaprostol) for the treatment of gastric and duodenal ulcers. An allenic PGE2 derivative, enprostil is both antisecretory (acid, gastrin) and cytoprotective.
White or off-white waxy solid, softens at 30°C, liquefies at 46°C. Very soluble in water or ethanol or propylene glycol or propylene carbonate. Extremely soluble in water, soluble in ethanol or propylene glycol or propylene carbonate.UV Maximum Absorption (methanol): 220, 265, 271, 277nm (ε10200, 1380, 1740, 1450).
Enprostil is a synthetic analogue of prostaglandin E2 and was found to be effective in the treatment of patients with duodenal or gastric ulcers.
Antisecretory; antiulcerative.
Moderately toxic by ingestion.
