AN-0128

Chemical Properties

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Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)^[2]
Dosage:	1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle
Administration:	Daily topical daub for 7 days
Result:	Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)^[2]
Dosage:	5% with Total toothpaste
Administration:	Applied daily via a cotton-tip applicator. for 7 days
Result:	Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss.