Prostaglandin F2α diethyl amide

Prostaglandin F2α diethyl amide (PGF2α-NEt2) is an analog of PGF2α (Item No. 16010) in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.WARNING This product is not for human or veterinary use.

[1] BITO L Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds[J]. Experimental eye research, 1984, 38 2: Pages 181-194. DOI: 10.1016/0014-4835(84)90102-7
[2] D.F WOODWARD PHD. The Pharmacology of Bimatoprost (Lumigan™)[J]. Survey of ophthalmology, 2001, 45: Pages S337-S345. DOI: 10.1016/s0039-6257(01)00224-7
[3] KIRK M MAXEY MD  Jennifer L B  Jennifer L Johnson MS. The Hydrolysis of Bimatoprost in Corneal Tissue Generates a Potent Prostanoid FP Receptor Agonist[J]. Survey of ophthalmology, 2002, 47: Pages S34-S40. DOI: 10.1016/s0039-6257(02)00323-5