CINANSERIN HYDROCHLORIDE
CINANSERIN HYDROCHLORIDE 性质
| 密度 | 1.22 g/cm3 |
|---|---|
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMSO：125 mg/mL（331.62 mM；需要超声） |
| 形态 | 粉末 |
| 水溶解性 | Soluble to 50 mM in water |
CINANSERIN HYDROCHLORIDE 用途与合成方法
|
5-HT 2 Receptor 41 nM (Ki) |
3C-like proteinase
|
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL
pro
, HCoV-229E 3CL
pro
, with the K
D
values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL
pro
and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL
pro
.
The IC
50
values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL
pro
are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC
50
values for HCoV-229E 3CL
pro
are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C
pro
at concentrations up to 200 μM.
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
| Animal Model: | Male Wistar rats (250 g) underwent thermal injury |
| Dosage: | 5 mg/kg |
| Administration: | Intravenous injection; for 2 hours |
| Result: | Significantly reduced systemic burn edema to shamburn levels.. |
CINANSERIN HYDROCHLORIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-100943 | 5 mg | 1593 | ||
| 2024-01-25 | HY-100943 | CINANSERIN HYDROCHLORIDE | 54-84-2 | 10mg | 2550 |
