α-acetyl Boswellic acid is a pentacyclic triterpene and isomer of β-acetyl-boswellic acid originally isolated from B. serrata. It inhibits LPS-induced TNF-α mRNA expression in monocytes as well as NF-κB activity in HEK293 cells when used at a concentration of 10 μM. α-acetyl Boswellic acid also inhibits phosphorylation of IκBα mediated by IκB kinases (IKKs) in monocytes.
Acetyl-α-boswellic Acid is a selective inhibitor of COX-1. It also inhibits NF-KB signaling in LPS-stimulated monocytes.
ChEBI: 3-alpha-O-acetyl-alpha-boswellic acid is a triterpenoid. It has a role as a metabolite.
[1] TATIANA SYROVETS. Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.[J]. Journal of immunology, 2005, 174 1: 498-506. DOI:
10.4049/jimmunol.174.1.498
