2'-去氧-2'-氟-2'-C-甲基胞苷
2'-去氧-2'-氟-2'-C-甲基胞苷 性质
| 熔点 | 216-218℃ |
|---|---|
| 沸点 | 482.4±55.0 °C(Predicted) |
| 密度 | 1.67 |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 酸度系数(pKa) | 12.86±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 稳定性 | 吸湿性 |
2'-去氧-2'-氟-2'-C-甲基胞苷 用途与合成方法
IC50: 0.6 μM (HCV replication)
PSI-6130 exhibits potent and specific inhibitory activity against HCV RNA replication mediated by the NS5B polymerase. Both PSI-6130 inhibit HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with mean EC 50 values of 0.51 and 0.30 μM, respectively. PSI-6130 inhibits 40% human serum with EC 50 of 0.51 μM. PSI-6130 inhibits HCV replication with a mean IC 50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC 50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC 50 of 0.13 μM and K i of 0.023 μM.
2'-去氧-2'-氟-2'-C-甲基胞苷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 | 817204-33-4 | 2mg | 887 |
| 2024-11-08 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 | 817204-33-4 | 10mM * 1mLin DMSO | 1265 |
