6-Methoxynicotinamide

Product Name6-Methoxynicotinamide
CAS7150-23-4
MFC7H8N2O2
MW152.15
EINECS604-604-1
MOL File7150-23-4.mol

Chemical Properties

Melting point	178-180°C
Boiling point	301.6±22.0 °C(Predicted)
Density	1.213±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	15.17±0.50(Predicted)
color	Off-White to Pale Beige
InChI	InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
InChIKey	KXDSMFBEVSJYRF-UHFFFAOYSA-N
SMILES	C1=NC(OC)=CC=C1C(N)=O

Safety Information

WGK Germany	WGK 3
HS Code	2933399990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2

Usage And Synthesis

Description

JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.

Uses

6-Methoxynicotinamide (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO).

Biological Activity

JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM.

in vitro

JBSNF-000088 (6-Methoxynicotinamide) has IC ₅₀ values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells.

target