TERT-BUTYL 5-BROMOISOINDOLINE-2-CARBOXYLATE

24424-99-5

127168-84-7

201940-08-1

General procedure for the synthesis of tert-butyl 5-bromoisoindoline-2-carbonate from di-tert-butyl dicarbonate and 5-bromoisoindoline: to a solution of 5-bromoisoindoline (6 g, 30 mmol) in tetrahydrofuran (THF, 100 mL) was added a saturated sodium carbonate solution (25 mL), followed by di-tert-butyl dicarbonate (33 g, 151 mmol). The reaction mixture was stirred at room temperature for 2 hours, followed by concentration under reduced pressure. The residue was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated again under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 10:1, v/v) to afford the target product tert-butyl 5-bromoisoindoline-2-carboxylate (9 g, approx. 100% yield). lc-MS: 298 [M+1].